Leonate Tablet 
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USED FOR:
Malaria
COMPOSITION:
Artesunate (50mg)
Sulfadoxine (500mg)
Pyrimethamine (25mg)
Therapeutic Uses:
anti malarials
Interaction with alcohol is unknown. Please consult your doctor.
WEIGH RISKS VS BENEFITS
Leonate Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
CAUTION
Leonate Tablet is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Leonate Tablet may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
CAUTION
Leonate Tablet should be used with caution in patients with kidney disease. Dose adjustment of Leonate Tablet may be needed. Please consult your doctor.
CAUTION
Leonate Tablet should be used with caution in patients with liver disease. Dose adjustment of Leonate Tablet may be needed. Please consult your doctor.
Uses of Artesunate
Artesunate is used in the treatment of malariaIt is not used to prevent malaria or to treat severe malaria (where it has affected the brain, lungs or kidneys).
How to use Artesunate
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Leonate Tablet works
Artesunate acts by producing free radicals within the malarial parasite, which kills it.
Common Decreased appetite, Headache, Vomiting, Abdominal pain, Cough.
Expert advice for Artesunate
Do not start or continue the artesunate tablets and consult your doctor If you are allergic (hypersensitive) to artesunate.Do not start or continue the artesunate tablets and consult your doctor you are in first 3 months of pregnancy  or If you are breast feeding.Do not drive or operate machinery after taking artesunate because you may feel sleepy.
Q. What is artesunate amodiaquine/ Winthrop/artesunate injection?
These are trade names of artesunate containing products. It is used for the treatment of malaria. Patients should follow the advice of the doctor regarding its use
Q. Does artesunate contain sulphur?
No, it does not contain sulphur
Q. Where does Artesunate come from?
It is derived from Artemisinin tree.
Q. Is Artesunate banned in India?
No, it is available in India with doctor's prescription only
Q. Why is artesunate better than quinine?
Intramuscular or intravenous injection of artesunate has shown better treatment effects than quinine. Always consult your doctor regarding its use
Q. How does Artesunate work?
It acts by producing free radicals which kills the malarial parasite (Plasmodium)
Uses of Sulfadoxine
Sulfadoxine is used in the treatment of malaria and bacterial infections.
How to use Sulfadoxine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Leonate Tablet works
Sulfadoxine is an antibiotic. It stops the bacteria from producing folic acid, a nutrient required for bacterial multiplication.
Common Nausea, Vomiting, Skin rash, Allergic reaction.
Expert advice for Sulfadoxine
Take sulfadoxine along with food to minimize gastrointestinal side effects.
Take sulfadoxine with plenty of water to prevent crystalluria (crystals found in the urine when performing a urine test).
Avoid excessive sun exposure and wear protective clothing while taking sulfadoxine, as it may increase sensitivity to sunlight.Â
Seek immediate medical attention if you experience signs of rash or any other allergic reaction or folate deficiency (low level of folic acid in the body).
You will be regularly monitored for complete blood count, liver function tests, analysis of urine for crystalluria if sulfadoxine is administered for > 3 months.
Do not drive or operate any machinery while taking sulfadoxine as it may cause dizziness.
Do not take if patient is allergic to sulfadoxine or any of its ingredients.
Do not take if patients with impaired kidney or liver function, blood dyscrasias (a diseased state of blood), folate deficiency, severe allergy or bronchial asthma, G6PD deficiency.
Do not given to Children less than 2 months.
Do not given to regnant women at term and breastfeeding women.
Uses of Pyrimethamine
Pyrimethamine is used in the treatment of malaria.
How to use Pyrimethamine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Leonate Tablet works
Pyrimethamine is a weak base that reaches high concentration within the malarial parasite and causes accumulation of toxic heme pigment, which kills it.
Common Abnormal bruising, Abnormal skin pigmentation, Anemia, Change in blood test results, Dizziness, Headache, Vomiting, Weakness, Diarrhoea, Nausea.
Expert advice for Pyrimethamine
Pyrimethamine when given with sulphonamide, it should be given with folic acid (vitamin) supplement.
Do not use pyrimethamine if you are allergic to pyrimethamine or any other ingredient.
Do not take pyrimethamine if you have megaloblastic anemia due to folate deficiency.
Do not take pyrimethamine if you have kidney or liver problems; fits (seizures); depression; bone marrow problems; stomach or bowel problems (eg, malabsorption syndrome); phenylketonuria, or alcoholism.
Q. What is Pyrimethamine is used for?
Pyrimethamine is used to treat toxoplasmosis and treat or prevent malaria infections along with other medicines
Q. How does Pyrimethamine work?
Pyrimethamine is an antiparasitic and works by killing the parasites or preventing their growth in the blood stream.
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